22,500+ Happy Customers

4.9/5 (1612+ Reviews)

90 Day Guarantee

"I actually got to the point of considering knee surgery — 5 weeks after trying Total Renew, I'm back to gardening pain-free..." Nora T., 63

A deep-penetrating topical protocol that does three things other products miss: calms joint inflammation, supports the natural balance that keeps your cartilage intact, and delivers the building blocks to help rebuild it — applied right over the knee, back, hip, or hands that ache.

Calms inflammation for fast-building comfort

Supports healthy cartilage balance, not just pain masking

Deep-penetrating actives led by Melittin

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4.9/5 (1612 Reviews)

Total Renew — Advanced Joint & Nerve Relief Protocol

Deep-penetrating formula

Triple-action technology

Clinically-tested actives

Non-greasy, odor-free

Free Worldwide Shipping

on orders over $60

90-Day Money Back Guarantee

Satisfaction guaranteed

WARNING: Low Stock Notice

This product sold out 12 times last year. We encourage you to take advantage of the limited sale and buy now. Subscribing protects you against future stock outs.

PS: Only available here, don’t buy fakes on Amazon/eBay

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Don't Take Our Word For It

Join 22,500+ People Who Finally Found Relief

For three years, I used a walker just to get from the bedroom to the kitchen. Six weeks into Total Renew, I realized the walker was still against the wall — and I'd completely forgotten about it. On my daughter's wedding day, I took her arm and walked her down that aisle without thinking about my knees once.

Robert M., 67

Verified Buyer

For seven years, my husband Hank knelt in front of me every morning to put on my shoes. He never complained. But every time, something inside me broke a little. In week five of Total Renew, I bent down and did it myself — no pain, no help. It wasn't about the shoes. It was about my dignity.

Gloria T., 62

Verified Buyer

When arthritis took my fingers, I couldn't hold a screwdriver or button my own shirt. After seven weeks of applying Total Renew, I sat at my workbench and repaired two watches in the same week. My hands are back. And honestly, so am I.

Arthur B., 73

Verified Buyer

I used to make excuses every time Sophie asked me to play outside. I had a knee replacement scheduled and I was terrified. Six weeks into Total Renew, I canceled the surgery. Eight weeks in, I pushed her on those swings until my arms got tired — not my knees.

Linda W., 68

Verified Buyer

Clinically-Studied Ingredients

Designed to Do What Most Joint Products Can't

Triple-Action, Not Just Pain Masking

Most creams numb the feeling for an hour and call it relief. Total Renew works on three fronts at once — calming inflammation, supporting your cartilage's natural balance, and helping rebuild the tissue. Real support, not a 20-minute distraction.

Calms the Inflammation Behind the Discomfort

Joint inflammation is what tips your cartilage from "renewing" to "breaking down." Total Renew's actives — led by Boswellia — are studied for working on those same inflammatory pathways, helping quiet the discomfort at its source.

Supports Healthy Cartilage Balance

Your body constantly renews cartilage using enzymes called MMPs — but inflammation throws them out of balance, and they start breaking it down faster than you rebuild. Total Renew is formulated with actives studied for their interaction with MMP-3 and MMP-13, helping support that balance again.

Helps Rebuild, From the Outside In

With the balance supported, rebuilding finally matters. Type II Collagen and low-molecular-weight Hyaluronic Acid penetrate to the joint area to deliver cartilage's building blocks and restore the fluid that brings back the glide. Less grinding. More glide.

They Tried Everything. Watch What Finally Worked

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   Nature’s Best in Balance   

Pure and natural ingredients:

Melittin (Bee Venom Extract)

The cornerstone of the formula. Research from Washington University in St. Louis explored how Melittin, applied topically, penetrates through the skin to reach joint tissue — where studies have examined its potential interaction with the inflammatory signaling associated with cartilage-related enzymes (MMPs). Most companies won't touch it because it's expensive and difficult to source. We built our entire formula around it.

Boswellia Serrata

Featured in research published in the Indian Journal of Pharmaceutical Sciences, Boswellia has been studied for its interaction with the same inflammatory pathways researchers associate with joint discomfort. It works alongside Melittin to support a calm, comfortable feeling around the joint area.

Hyaluronic Acid 

Standard hyaluronic acid sits on the skin's surface and never reaches the joint area. The low-molecular-weight version we use is small enough to actually penetrate where it can do the most good — designed to support the natural fluid environment around the joint. Less grinding. More glide.

Apigenin (from Chamomile)

A flavonoid naturally found in chamomile that researchers have studied for its interaction with MMP-3 and MMP-13 — enzymes the body produces during periods of joint inflammation. A clinical paper from the University of Medical Sciences in Shiraz documented meaningful comfort improvements and better mobility with topical chamomile use on stiff knees.

Type II Collagen

Formulated at a molecular weight specifically designed to be absorbed through the skin. Clinical research at Harvard Medical School has explored this form of collagen and how the body's signaling responds to it — a key reason it's part of our long-term protocol.

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One Formula · Every Joint

Wherever It Aches, That's Where You Use It

Total Renew's triple-action formula goes to work right at the spot — apply it directly over the joint that's bothering you, anywhere on the body.

Total Renew applied to the knee

Knees

For stairs, standing up, and kneeling without a second thought.

Total Renew applied to the lower back

Lower Back

For mornings when getting out of bed shouldn't feel like a workout.

Total Renew applied to the hip

Hips

For walking farther and sleeping through the night on your side.

Total Renew applied to the shoulder

Shoulders

For reaching overhead and lifting without the catch.

Total Renew applied to the hands and fingers

Hands & Fingers

For opening jars, gripping, and stiff-free mornings.

Total Renew applied to the neck

Neck

For the tension that builds from screens and long days.

Same triple-action formula, applied wherever you need it most. Calm. Rebalance. Rebuild — right at the source.

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Most Creams Quit After 20 Minutes. Here's What 12 Weeks Builds.

Total Renew works on a different clock — under the surface, one week at a time. Here's the 12-week timeline customers describe most often.

1
Total Renew cream being massaged into a knee in warm natural light Weeks 1–3 · Delivery

Reaches the Source

What's happening

The deep-penetrating delivery system carries the actives — led by Melittin — past the surface and into the joint area. No detour through the stomach. No greasy residue sitting on the skin.

What you may notice

It absorbs in seconds and disappears. No smell. By the end of the first weeks, many customers say the joint simply feels less tight — not numbed, just quieter.

2
Older woman sitting on the floor playing with her grandchildren Weeks 4–6 · Calm

Calms the Environment

What's happening

Boswellia Serrata and Apigenin go to work on the inflammatory pathways researchers link to a restless joint environment — the same MMP activity most creams ignore entirely.

What you may notice

Morning stiffness that used to set the tone for the whole day starts to ease sooner. The first few steps out of bed stop being the hardest part.

Verified · Week 5
"My grandkids stopped asking me to get down on the floor with them — they'd glance at my knees first. Week five, I sat cross-legged on the rug and built a whole block city with them. I wasn't the grandma who watches anymore. I was the grandma who plays."
— Marlene K., 64 · Verified Buyer
3
Man walking comfortably outdoors without bracing Weeks 6–9 · Glide

Restores the Glide

What's happening

Low-molecular-weight Hyaluronic Acid — small enough to actually reach where standard HA never does — supports the natural fluid environment around the joint. Less grinding. More glide.

What you may notice

This is the window where most stories turn. Movement you'd quietly stopped doing comes back — stairs, kneeling, a walk that doesn't end early.

Verified · Week 6
"I used to park as close to the store as I could and still dread the walk in. By week six I parked at the far end without thinking, crossed the whole lot, and realized halfway I'd forgotten to brace for it. I don't plan my days around walking distance anymore. I just go."
— Dennis P., 69 · Verified Buyer
4
Older woman fastening the buttons on her coat with steady hands Weeks 9–12 · Renew

Builds Lasting Comfort

What's happening

Type II Collagen — formulated at a molecular weight designed to absorb through the skin — anchors the back half of the protocol. By week 12 the routine has had the time it needs to make a difference that holds.

What you may notice

The gains stop being a surprise and start being normal. Most customers shift to a simple maintenance routine from here and keep the ground they gained.

Verified · Week 8
"Buttons defeated me. My daughter had to do up my blouse like I was a child again. Eight weeks in, I fastened every button on my coat — and then I threaded a needle. My hands answer to me again. At 71, that's not a small thing. That's everything."
— Frances O., 71 · Verified Buyer

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90-DAY MONEY-BACK GUARANTEE

Here's the deal: Give Total Renew three full months. Apply it daily. Pay attention to how you feel.

 

If at the end of 90 days you're not genuinely happy with the difference — for any reason at all, or no reason — just send our team an email and we'll refund every dollar. No questions. No hoops. No "send the jars back" runaround.

 

You keep the jars. We send you the money. That's it.

 

We can offer that because we know what happens when people actually use Total Renew the way it was designed to be used. The risk is entirely ours. All you have to do is start.

Why 22,500+ People Swear By Total Renew

22,500+ customers, and the stories keep sounding the same. Here's a sample, unedited.

4.9 ★★★★★ Based on 1,612 reviews Rated Excellent
5 ★ 92%
4 ★ 6%
3 ★ 1%
2 ★ 1%
1 ★ 0%
★★★★★ Verified

Tried every cream at the pharmacy, none lasted more than an hour. This one's different. Took a few weeks but now I do the basement stairs with the laundry and don't even think about it.

Carol D., 66

★★★★★ Verified

My fingers wouldn't close around my coffee mug in the mornings. Been using it on my hands about a month now and I'm gripping the mug again. Doesn't smell either, which is a plus.

Wayne T., 71

★★★★★ Verified

Buddy and I do our whole morning loop again. Used to cut it in half cuz of my knees. Not anymore.

Pat S., 63

★★★★★ Verified

Shoulder had me asking my wife to reach the top shelf for years. Put it on every day, gave it time, and by month two I'm putting the plates away myself. Felt like getting something back.

Harold M., 74

★★★★★ Verified

Getting out of the car used to be a whole production. Now I just swing my legs out and go. Not greasy, no weird smell. Happy customer.

Janet R., 68

★★★★★ Verified

Gave up my garden two summers ago, my lower back couldn't take the kneeling. This spring I planted the whole row myself. Wish I'd found this stuff sooner honestly.

Bill K., 70

★★★★★ Verified

Told my husband I'd just watch at our anniversary. Ended up dancing the whole song. He didn't say anything, just held on. That says it all.

Donna F., 65

★★★★☆ Verified

Didn't feel much the first couple weeks and almost quit. Glad I stuck with it. Played a full 18 by week seven and woke up fine. Only knock is I wish it kicked in faster.

Eugene W., 72

★★★★★ Verified

My hands had quit on me. Finished a whole baby blanket for my granddaughter last week, first thing I've made in years. Works if you're consistent with it.

Sharon L., 69

FAQ

How is Total Renew different from other joint creams I've tried before?

Most joint creams only numb the feeling for an hour, and most pills only try to replace cartilage. Total Renew is built to do all three jobs that actually help: calm the inflammation behind the discomfort, support your cartilage's natural balance, and deliver the building blocks to help rebuild it — applied right where you hurt, so it reaches the joint instead of getting lost in your body like a pill. It's a real protocol, not a quick trick. That's why people who've tried everything tell us this is finally different.

I'm 75 years old. Is my condition too advanced for this to work?

Not even close. Total Renew is designed for adults of every age looking to support their joint comfort and daily mobility — and some of our happiest customers are in their 70s and 80s. The formula is gentle enough for daily use and works best when applied consistently throughout the full 6-month protocol. Age is not the obstacle people think it is.

Can I take Total Renew with other supplements or medications?

Total Renew is a topical cream made with natural ingredients, so it's generally easy to incorporate alongside other wellness products. That said, if you're managing a medical condition or taking prescription medication, we always recommend a quick chat with your healthcare provider before adding anything new to your routine

How much should I order?

Honestly? As much as you can. The full protocol is six months for a real reason — supporting joint comfort and mobility takes consistency, and customers who go all-in on the 6-jar package are the ones who write us the kinds of stories you read above. The per-jar price drops significantly, shipping is free, and you're protected by the 90-day guarantee. If you'd rather try it first, the 2-jar option is a good place to start — but re-orders aren't guaranteed at today's discount.

How soon will I start to feel results?

Every body is different, but most customers tell us they start noticing how their joints feel within the first few weeks. Some feel it sooner. The full six-month protocol is designed to give your routine the time it needs to make a real, lasting difference — not just a quick win.

How long does shipping take?

Delivery times vary depending on your location. For the United States, delivery generally takes 10 to 15 business days. For other countries, it can range from 10 to 20 business days, depending on the region. Once your order is dispatched from NatureOne Lab facilities, you will receive a tracking code via email and SMS to track the delivery in real time to your door.

Can I use Total Renew on multiple joints at the same time?

Absolutely. Many customers apply Total Renew to knees, hands, shoulders, hips, and lower back — wherever they want a little extra comfort. A small amount goes a long way, so a single jar covers more ground than you'd expect.

Is there anyone who should NOT use Total Renew?

Total Renew is made with natural ingredients and is well-tolerated by most adults. However, if you're allergic to bee products, pregnant, nursing, or managing a medical condition, please consult a qualified healthcare professional before use.

What if it doesn't work for me?

Then you don't pay for it. Contact our team within 90 days and we'll refund every dollar — and you keep the jars. The risk is entirely ours. Always has been.

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Free Worldwide Shipping on orders over $60

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Free Shipping

Free Worldwide Shipping on orders over $60

Full Refund

90 Day Money Back Guarantee

Secure Online Payment

Technology used by major banks